[S29] Rabbit Anti-rIrisin (FNDC5) Antiserum, Academy Bio-medical Company, Inc.

[S29] Rabbit Anti-rIrisin (FNDC5) Antiserum

IRS-R1C

Academy Bio-Medical Company, Inc.

  • $221.00


Host Species: Rabbit
Antigen: Recombinant Irisin constructed from the coding sequence of mouse (NM 027402.3).
Specificity

Mouse, Human. Dilution for immunoblot and ELISA range: 2,000 to 160,000. Centrifuge before use. 

Use: The antibody can be used for detection of Irisin in plasma, immunosassays, immunoblots.
Storage: Freeze-dried product should be stored refrigerated until opened. After opening, restore to suggested ml volume with distilled water. If it is not completely clear after standing for 1-2 hours at room temperature, centrifuge the product. It is stable for several weeks at 4°C as an undiluted liquid. Do not use for more than one day after dilution. For extended storage after reconstitution, we suggest aliquot to avoid repeated freezing and thawing; or the addition of an equal volume of glycerol to make a final glycerol concentration of 50%, followed by storage at -20°C. The concentration of protein and buffer salts will decrease to one-half of the original after the addition of glycerol.

 

*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.

 

Importance

The exercise-inducible myokine Irisin (Boström, et al. 2012) is secreted by cleavage from the transmembrane precursor, FNDC5. Circulating Irisin govern a wide variety of cellular processes relevant to browning, angiogenesis, wound healing, bone mass, and metabolism.

Boström, et al. 2012. A PGC1-α-dependent myokine that drive brown-fat-like development of white fat and thermogenesis. Nature, 481: 463-468

 


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