[A28] Rabbit Anti-Irisin (FNDC5) Polyclonal Antibody

IRA-R1c

Academy Bio-Medical Company, Inc.

  • $630.00


Host Species: Rabbit
Concentration: 1 mg/ml (OD 1.35 / 280 nm)
Antigen: Recombinant Irisin constructed from the coding sequence of mouse (NM 027402.3).
Purification: Affinity purified
Buffer: 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2
Specificity

Mouse, Human. Dilution for Immunoblot & ELISA range: 1,000 to 4,000. Centrifuge before use.

Use: The antibody can be used for detection of Irisin in plasma, immunosassays, immunoblots.
Storage: -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing.

 

*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.

Importance

The exercise-inducible myokine Irisin (Boström, et al. 2012) is secreted by cleavage from the transmembrane precursor, FNDC5. Circulating Irisin govern a wide variety of cellular processes relevant to browning, angiogenesis, wound healing, bone mass, and metabolism.

Boström, et al. 2012. A PGC1-α-dependent myokine that drive brown-fat-like development of white fat and thermogenesis. Nature, 481: 463-468


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