[A26] Goat Anti-CBL (Carbamyl-lysine) Polyclonal Antibody, Academy Bio-medical Company, Inc.

[A26] Goat Anti-CBL (Carbamyl-lysine) Polyclonal Antibody

CBL30A-G1a

Academy Bio-Medical Company, Inc.

  • $281.00


Host Species: Goat
Concentration: 1 mg/ml (OD 1.35 / 280 nm)
Antigen: CBL-KLH
Purification: Affinity purified
Buffer: 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2
Specificity

Specifically binds to CBL. Dilution for immunoblot and ELISA range: 1,000 to 8,000. (A slight amount of precipitation may have occurred during storage due to the natural properties of these antibodies; please centrifuge before use.).

Use:

The antibody can be used for detection of Carbamylation in plasma, lipoproteins, and other CBL containing proteins, using for immunoassays, immunoblots, enzyme conjugation, or biotinylation.

Storage: -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing.

 

*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.

Importance

Carbamylation is a spontaneous nonenzymatic modification of proteins and amino acids by urea-derived isocyanate, which is generally present in human serum and is increased in uremic patients (Kraus and Kraus, 2001).

Proteins carbamylated at lysine or the terminal protein amino acids may play an important role in Chronic renal failure subjects in the development of atherosclerosis and cardiovascular diseases (Raine et al., 1991; Culleton et al., 1999).

Culleton BF, Larson MG, Wilson PW, Evans JC, Parfrey PS, Levy D. Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency. Kidney Int 1999; 56: 2214–9.

Kraus LM, Kraus AP Jr. Carbamoylation of amino acids and proteins in uremia. Kidney Int Suppl 2001; 78: S102–7.

Raine AE, MacMahon SH, Selwood NH, Wing AJ, Brunner FP. Mortality from myocardial infarction in patients on renal replacement therapy. Nephrol Dial Transplant 1991; 6: 902.

 

Citations

[A26][A27] 2019 Chang, Chiz-Tzung; Lim, Yun-Ping; Lee, Chi-Wen; Liao, Hsin-Yi; Chen, Feng-Yu; Chang, Chia-Ming et al. (2019): PON-1 carbamylation is enhanced in HDL of uremia patients. In Journal of Food and Drug Analysis 27 (2), pp. 542–550. DOI: 10.1016/j.jfda.2018.09.007.
[A26][A27] 2018 Eiserich, Jason P.; Ott, Sean P.; Kadir, Tamara; Morrissey, Brian M.; Hayakawa, Keri A.; La Merrill, Michele A.; Cross, Carroll E. (2018): Quantitative assessment of cyanide in cystic fibrosis sputum and its oxidative catabolism by hypochlorous acid. In Free Radical Biology and Medicine 129, pp. 146–154. DOI: 10.1016/j.freeradbiomed.2018.09.007.

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